Diethylpropion is a sympathomimetic amine that possesses pharmacological properties similar to amphetamine. Although the exact mechanism of action has not been established, it is thought that appetite suppression is produced by a stimulant effect on the satiety centre in the hypothalamic and limbic regions of the brain. Secondary actions include CNS stimulation and blood pressure elevation. Diethylpropion acts primarily on adrenergic pathways to increase the release of norepinephrine from nerve terminals and inhibit its reuptake; therefore, its consider an indirect-acting sympathomimetic. There is evidence that diethylpropion may also provide some direct stimulation of the nerve terminal to produce the pharmacologic response. You can Buy DIETHYLPROPION Online with guaranteed delivery.
Due to its vasopressor effects, diethylpropion is contraindicate in patients with advance arteriosclerosis, severe hypertension, or pulmonary hypertension. Diethylpropion is not recommend in patients with cardiac arrhythmias, heart murmur, or valvular heart disease. Valvular heart disease is associate with the use of some anorectic agents such as fenfluramine and dexfenfluramine.
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Cardiac valvulopathy has been very rarely reporting with diethylpropion monotherapy, but the causal relationship remains uncertain. Possible contributing factors include use for extended periods of time, higher than the recommended dose, and/or use in combination with other anorectic drugs. Baseline cardiac evaluation should be considere to detect preexisting valvular heart diseases or pulmonary hypertension prior to initiation of diethylpropion treatment. An echocardiogram during and after treatment could be useful for detecting any valvular disorders which may occur. In a case-control epidemiological study, the use of anorectic agents, including diethylpropion, was associate with an increase risk of developing pulmonary hypertension, a rare, but often fatal disorder.
The use of anorectic agents for longer than 3 months was associate with a 23-fold increase in the risk of developing pulmonary hypertension. Increase risk of pulmonary hypertension with repeat courses of therapy cannot be exclude. The onset or aggravation of exertional dyspnea or unexplained symptoms of angina pectoris. Syncope, or lower extremity oedema suggest the possibility of occurrence of pulmonary hypertension. Under these circumstances. Diethylpropion should be immediately discontinue, and the patient should be evaluate for the possible presence of pulmonary hypertension. The potential risk of possible serious adverse effects such as valvular heart disease and pulmonary hypertension should be assessed carefully against the potential benefit of weight loss.