Description
Structure
A solution of ethyl methyl amine (10Og, 1.69mol) in dichloromethane (1.51) is added dropwise to a slurry of sodium bicarbonate (284g, 3.384mol) and triphosgene (332g, 1.117mol) in dichloromethane (21) at 10-15°C over 2 hours. The reaction mixture is stirred at room temperature for 3 hours. The reaction mass is filtered to remove sodium chloride and the filtrate is concentrated under vacuum to give 189g of ethyl methyl carbamoyl chloride as a light yellow oil (yield: 92percent). The process of was repeated but the solvent was changed to dichloromethane. The other conditions were similar. The results are provided in Table 2 below.Table 2The yield was found to be consistent a